"Once you have a cold or upper respiratory tract infection, that virus can then settle into the sinuses and cause inflammation as well," said Dr. What can start as inflammation in your sinuses from a respiratory infection, allergies or environmental pollutants can spark a sinus infection when the lining of the sinuses becomes inflamed and swollen, causing mucus to become trapped and germs to grow. Sinusitis occurs when the lining of the sinus or nasal cavity becomes inflamed.
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